Genetic Engineering and Biosynthesis Technology: Keys to Unlocking the Chains of Phage Therapy

Phages possess the ability to selectively eliminate pathogenic bacteria by recognizing bacterial surface receptors. Since their discovery, phages have been recognized for potent bactericidal properties, making them a promising alternative antibiotics in context of rising antibiotic resistance. However, rapid emergence phage-resistant strains (generally involving temperature phage) and limited host range most phage hindered antibacterial efficacy, impeding full potential. In recent years, advancements genetic engineering biosynthesis technology facilitated precise phages, thereby unleashing potential as novel source agents. this review, we present comprehensive overview diverse strategies employed engineering, well discuss benefits drawbacks terms effect.